Search results for "Subclinical atherosclerosis"

showing 10 items of 14 documents

Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness…

2011

Carotid intima media thickness (cIMT) and plaque determined by ultrasonography are established measures of subclinical atherosclerosis that each predicts future cardiovascular disease events. We conducted a meta-analysis of genome-wide association data in 31,211 participants of European ancestry from nine large studies in the setting of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium. We then sought additional evidence to support our findings among 11,273 individuals using data from seven additional studies. In the combined meta-analysis, we identified three genomic regions associated with common carotid intima media thickness and two different regions a…

AgingMultifunction cardiogramGenome-wide association studyDiseaseCoronary Artery Disease030204 cardiovascular system & hematologyCarotid Intima-Media ThicknessCoronary artery diseaseCohort Studies0302 clinical medicinecardiovascular diseaseRisk FactorsAging/geneticsgeneticsMyocardial infarctionEuropean Continental Ancestry Group/geneticsriskPlaque0303 health scienceseducation.field_of_studyGenomeCoronary Artery Disease/geneticsHeartSingle NucleotidePlaque Atherosclerotic/geneticsMiddle AgedPlaque Atherosclerotic3. Good healthPhenotypeHeart/physiopathologyCardiologyHumanAdultmedicine.medical_specialtygenetic epidemiologyGenotypesubclinical atherosclerosisPopulationSingle-nucleotide polymorphismBiologyPolymorphism Single NucleotideWhite PeopleArticle03 medical and health sciencesSDG 3 - Good Health and Well-beingInternal medicinemedicinecohort studyHumanscarotid intima media thicknessGenetic Predisposition to DiseasePolymorphismeducation030304 developmental biologyAgedAtherosclerotic/geneticsGenome Humanmedicine.diseaseAtherosclerosismeta-analysisAtherosclerosis/geneticsIntima-media thicknessGenetic LociGenome-Wide Association Study
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Subclinical atherosclerosis and history of cardiovascular events in Italian patients with rheumatoid arthritis: Results from a cross-sectional, multi…

2017

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Blood GlucoseMalerheumatoid arthritisCross-sectional studyType 2 diabetesTriglycerideArthritis Rheumatoid0302 clinical medicineRisk FactorsCardiovascular DiseasePrevalence030212 general & internal medicineMyocardial infarctionStrokeSubclinical infectionAged 80 and overMetabolic SyndromeMetabolic Syndrome XGeneral MedicineMiddle Agedinflammatory processCholesterolItalyCardiovascular DiseasesRheumatoid arthritisAtherosclerosiHypertensionComputingMethodologies_DOCUMENTANDTEXTPROCESSINGFemaleHumanResearch ArticleAdultmedicine.medical_specialtyAdolescentsubclinical atherosclerosisObservational Study03 medical and health sciencesYoung Adultcardiovascular eventsInternal medicinemedicineHumansTriglyceridesAged030203 arthritis & rheumatologyCross-Sectional Studiebusiness.industryRisk Factor6900medicine.diseaseAtherosclerosisCross-Sectional StudiesDiabetes Mellitus Type 2Physical therapyMetabolic syndromebusinessRheumatismtraditional cardiovascular risk factorMedicine
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Naïve hepatitis B e antigen-negative chronic hepatitis B patients are at risk of carotid atherosclerosis: A prospective study

2021

BACKGROUND There is an increased risk of atherosclerosis in patients with chronic hepatitis C or human immunodeficiency virus, but there is scarce data on hepatitis B virus infection. The hypothesis of this study is that hepatitis B virus infection increases the risk of carotid plaques and subclinical atherosclerosis in naïve hepatitis B e antigen (HBeAg) negative subjects. AIM To assess the rate of carotid plaques and subclinical atherosclerosis in naïve HBeAg negative subjects in comparison with a cohort of healthy controls. METHODS Prospective case-control collaborative study conducted in two tertiary hospitals. Four hundred and two subjects prospectively recruited at the outpatient clin…

Carotid Artery DiseasesHepatitis B virusmedicine.medical_specialtyIntima-media thicknessCardiovascular risk Carotid plaques Endothelial dysfunction Hepatitis B virus Intima-media thickness Subclinical atherosclerosis Carotid Intima-Media Thickness Hepatitis B e Antigens Humans Prospective Studies Carotid Artery Diseases Hepatitis B Chronicmedicine.disease_causeCarotid Intima-Media ThicknessGastroenterologyHepatitis B ChronicInternal medicinemedicineHumansOutpatient clinicCarotid plaquesSubclinical atherosclerosisEndothelial dysfunctionHepatitis B e AntigensProspective StudiesRisk factorProspective cohort studyHepatitis B virusbusiness.industryGastroenterologyGeneral MedicineOdds ratioHepatitis BCardiovascular riskmedicine.diseaseIntima-media thicknessHBeAgProspective StudybusinessWorld Journal of Gastroenterology
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Polyvascular subclinical atherosclerosis in familial hypercholesterolemia: The role of cholesterol burden and gender

2019

International audience; BACKGROUND AND AIM:Heterozygous familial hypercholesterolemia (HeFH) is a genetic disease characterized by a heterogeneous phenotype. The assessment of cardiovascular (CV) risk is challenging for HeFH. Cholesterol burden (CB) allows to estimate the lifelong exposure to high levels of cholesterol. The aim of this study was to analyze the distribution of subclinical atherosclerosis and the relationship between atherosclerosis and the CB in a sample of HeFH patients, focusing on sex-related differences.METHODS AND RESULTS:154 asymptomatic HeFH subjects underwent coronary-artery-calcium score (CACs) and Doppler ultrasound of carotid and femoral arteries. Yearly lipid pro…

Carotid Artery DiseasesMaleCarotid atherosclerosisPeripheral arterial atherosclerosisTime Factors[SDV]Life Sciences [q-bio]Endocrinology Diabetes and MetabolismMedicine (miscellaneous)Coronary Artery DiseaseDiseaseFamilial hypercholesterolemia030204 cardiovascular system & hematologySeverity of Illness Indexchemistry.chemical_compound0302 clinical medicineRisk FactorsAtherosclerosis; Calcium score; Cardiovascular disease; Cardiovascular risk; Cholesterol burden; Coronary artery calcium; Familial hypercholesterolemia; Peripheral arterial atherosclerosis; Adult; Aged; Asymptomatic Diseases; Biomarkers; Carotid Artery Diseases; Cholesterol; Coronary Artery Disease; Cross-Sectional Studies; Female; Femoral Artery; Genetic Predisposition to Disease; Humans; Hyperlipoproteinemia Type II; Male; Middle Aged; Paris; Peripheral Arterial Disease; Phenotype; Prevalence; Prognosis; Risk Assessment; Risk Factors; Severity of Illness Index; Sex Factors; Time Factors; Young AdultPrevalenceMedicineNutrition and Dietetics[SDV.MHEP.EM]Life Sciences [q-bio]/Human health and pathology/Endocrinology and metabolismMiddle AgedPrognosisCardiovascular diseaseCalcium score3. Good healthFemoral ArteryCholesterol burdenCholesterolPhenotypeAtherosclerosiCardiologyPopulation studyFemalemedicine.symptomCardiology and Cardiovascular MedicineAdultParismedicine.medical_specialtyFamilial hypercholesterolemia030209 endocrinology & metabolismRisk AssessmentAsymptomaticCoronary artery calciumHigh cholesterolHyperlipoproteinemia Type IIPeripheral Arterial DiseaseYoung Adult03 medical and health sciencesSex Factors[SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular systemInternal medicineHumansGenetic Predisposition to DiseaseAgedbusiness.industryCholesterolAtherosclerosismedicine.diseaseCardiovascular riskCross-Sectional StudieschemistrySubclinical atherosclerosisAsymptomatic DiseasesbusinessBiomarkers
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Relationship between carotid intima-media thickness and non valvular atrial fibrillation type.

2015

OBJECTIVE: Carotid intima-media thickness (cIMT) is a surrogate marker of subclinical atherosclerosis and it is able to predict both coronary and cerebral vascular events. No data exist on the association between cIMT and non valvular atrial fibrillation (NVAF) type. We conduct this study with the aim to analyze the association between abnormal cIMT and NVAF type. METHODS: A cross-sectional study of the "Atrial fibrillation Registry for Ankle-brachial index Prevalence Assessment-Collaborative Italian Study (ARAPACIS)" has been performed. Among 2027 patients enrolled in the ARAPACIS, 673 patients, who underwent carotid ultrasound examination to assess cIMT, were included in the study. RESULT…

Carotid Artery DiseasesMaleRegistrieSettore MED/09 - Medicina Internagenetic structuresCross-sectional studycarotid intima-media thickness; non valvular atrial fibrillation; ARAPACIScarotid atherosclerosisPredictive Value of TestComorbiditySubclinical atherosclerosiintima-media-thicknessCarotid intima-media thickneRisk FactorsAtrial Fibrillation80 and overPrevalencenonvalvular atrial fibrillation; intima-media-thickness; carotid atherosclerosisRegistriesCarotid intima-media thicknessStrokeAged 80 and overCarotid intima-media thickness; Paroxysmal non valvular atrial fibrillation; Persistent/permanent non valvular atrial fibrillation; Subclinical atherosclerosis; Aged; Aged 80 and over; Ankle Brachial Index; Asymptomatic Diseases; Atrial Fibrillation; Carotid Artery Diseases; Carotid Artery Common; Chi-Square Distribution; Comorbidity; Cross-Sectional Studies; Female; Humans; Italy; Linear Models; Logistic Models; Male; Middle Aged; Predictive Value of Tests; Prevalence; Registries; Risk Factors; Carotid Intima-Media ThicknessMedicine (all)Atrial fibrillationMiddle AgedCommonItalyPredictive value of testsnon valvular atrial fibrillationCardiologycardiovascular systemLinear ModelFemaleCardiology and Cardiovascular MedicineHumanmedicine.medical_specialtyLogistic ModelCarotid Artery CommonPersistent/permanent non valvular atrial fibrillationparoxysmal non valvular atrial fibrillation; persistent/permanent non valvular atrial fibrillation; subclinical atherosclerosis; carotid intima-media thicknessPredictive Value of TestsParoxysmal non valvular atrial fibrillationInternal medicinemedicineHumansAnkle Brachial Indexcardiovascular diseasesSubclinical atherosclerosisCarotid intima-media thickness; Paroxysmal non valvular atrial fibrillation; Persistent/permanent non valvular atrial fibrillation; Subclinical atherosclerosisAgedCross-Sectional StudieAsymptomatic DiseaseCarotid Artery DiseaseChi-Square Distributionbusiness.industrySurrogate endpointRisk Factornonvalvular atrial fibrillationmedicine.diseaseSettore MED/11 - Malattie Dell'Apparato CardiovascolareComorbidityParoxysmal Non Valvular Atrial Fibrillation Persistent/Permanent Non Valvular Atrial Fibrillation Subclinical Atherosclerosis Carotid Intima-Media ThicknessCross-Sectional StudiesLogistic ModelsIntima-media thicknessAsymptomatic DiseasesLinear ModelsARAPACISCarotid ArterybusinessChi-squared distribution
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Early Vascular Aging in Normotensive Patients With Systemic Lupus Erythematosus

2015

Connective tissue diseases, like systemic lupus erythematosus (SLE), are associated with early and accelerated atherosclerosis. Recently, the concept of “early vascular aging” (EVA) has been more widely accepted. Aortic stiffness is one of the important markers of EVA. We evaluated EVA and subclinical atherosclerosis, by measuring aortic pulse wave velocity (aPWV) and carotid intima–media thickness (cIMT), in 50 normotensive patients with SLE (mean age: 39 ± 12 years). We compared these participants with 50 age- and sex-matched patients with essential hypertension (EH) and 20 healthy controls. Each participant underwent 24-hour ambulatory blood pressure monitoring (ABPM), aPWV, and cIMT me…

Carotid Artery DiseasesMaleSettore MED/09 - Medicina InternaSLEBlood Pressure030204 cardiovascular system & hematologyEssential hypertensionCarotid Intima-Media Thickness0302 clinical medicineRisk FactorsLupus Erythematosus SystemicUltrasonography Doppler Colorskin and connective tissue diseasesPulse wave velocityAge FactorsBlood Pressure Monitoring AmbulatoryMiddle Agedcardiovascular systemCardiologyFemaleVascular agingAortic stiffnessEssential HypertensionCardiology and Cardiovascular MedicineAdultmedicine.medical_specialtyAmbulatory blood pressurePulse Wave AnalysisRenal Circulation03 medical and health sciencesVascular StiffnessInternal medicinemedicineHumansIn patientSettore MED/14 - Nefrologia030203 arthritis & rheumatologyAccelerated atherosclerosisbusiness.industryAtherosclerosismedicine.diseaseSettore MED/11 - Malattie Dell'Apparato CardiovascolareSettore MED/16 - ReumatologiaCase-Control StudiesSubclinical atherosclerosisAsymptomatic DiseasesVASCULAR DAMAGEAORTIC STIFFFNESSEARLY VASCULAR AGINGVascular ResistancebusinessAngiology
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Lipidomic profiling identifies signatures of metabolic risk

2020

Background: Metabolic syndrome (MetS), the clustering of metabolic risk factors, is associated with cardiovascular disease risk. We sought to determine if dysregulation of the lipidome may contribute to metabolic risk factors. Methods: We measured 154 circulating lipid species in 658 participants from the Framingham Heart Study (FHS) using liquid chromatography-tandem mass spectrometry and tested for associations with obesity, dysglycemia, and dyslipidemia. Independent external validation was sought in three independent cohorts. Follow-up data from the FHS were used to test for lipid metabolites associated with longitudinal changes in metabolic risk factors. Results: Thirty-nine lipids were…

Male0301 basic medicineResearch paperdhSL dihydrosphingolipidBMI body mass indexlcsh:MedicineATHEROGENIC LIPOPROTEINSBioinformaticsFHS Framingham Heart StudyPC phosphatidylcholinePESA Progression of Early Subclinical Atherosclerosis0302 clinical medicineFramingham Heart StudyRisk FactorsSAFHS San Antonio Family Heart StudyLC-MS/MS liquid chromatography-tandem mass spectrometryMedicineLongitudinal StudiesMetabolic riskPLASMA SPHINGOLIPID METABOLISMPOPULATIONlcsh:R5-920education.field_of_studySPHINGOMYELINCE cholesteryl esterDysglycemiaGeneral MedicineMiddle AgedLipidomePS phosphatidylserineCardiovascular diseaseLipidsMetabolic syndrome3. Good healthCARDIOVASCULAR-DISEASE030220 oncology & carcinogenesisHEARTMetS metabolic syndromeFemaleDisease SusceptibilityLGPL lysoglycerophospholipidSL sphingolipidlcsh:Medicine (General)LPE lysophosphatidylethanolamineAdultFDR false discovery rateTAG triacylglycerolPopulationCer ceramideCVD cardiovascular diseasePE phosphatidylethanolamineDENSITY-LIPOPROTEINRisk AssessmentGeneral Biochemistry Genetics and Molecular Biology03 medical and health sciencesAnimalsHumanseducationT2DM type II diabetes mellitusAgedLPC lysophosphatidylcholineSM sphingomyelinbusiness.industryCERAMIDElcsh:RHDL-C High density lipoprotein cholesterolBiomarkerLipid Metabolismmedicine.diseaseObesitySphingolipidCross-Sectional Studies030104 developmental biologyDyslipidemiaERF Erasmus Family StudyLipidomicsMetabolic syndromeINDUCED INSULIN-RESISTANCEbusinessDAG diacylglycerolBody mass indexBiomarkersDyslipidemiaMRM multiple reaction monitoringFASTING GLUCOSE
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The predictive role of C-reactive protein in patients with hypertension and subclinical atherosclerosis.

2009

Recent guidelines published by the joint European Society of Hypertension/European Society of Cardiology have suggested the inclusion of C-reactive protein (CRP) in the standard assessment of cardiovascular risk in hypertensive patients, but little data is available on the role of CRP in patients with carotid lesions. We studied in 472 subjects, 236 with and 236 without hypertension, gender- and age-matched, with and without early stages of atherosclerosis (e.g. those with asymptomatic intima-media thickness >0.9 mm), the influence of all the other traditional cardiovascular risk factors (e.g. older age, male gender, obesity, diabetes, smoking habit, family history of coronary artery diseas…

Malemedicine.medical_specialtySettore MED/09 - Medicina InternaInflammationAsymptomaticCoronary artery diseasePredictive Value of TestsRisk FactorsInternal medicineDiabetes mellitusCRP Hypertension Subclinical Atherosclerosis atherosclerosisInternal MedicinemedicineHumansIn patientFamily historyAgedbiologybusiness.industryC-reactive proteinMiddle Agedmedicine.diseaseC-reactive protein hypertension inflammation event atherosclerosisAtherosclerosisObesitySettore MED/11 - Malattie Dell'Apparato CardiovascolareCerebrovascular DisordersC-Reactive ProteinCase-Control StudiesHypertensionCardiologybiology.proteinFemalemedicine.symptombusinessBiomarkersFollow-Up StudiesInternal medicine journal
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Corrigendum to “Polyvascular subclinical atherosclerosis in familial hypercholesterolemia: The role of cholesterol burden and gender” [Nutr Metab Car…

2019

International audience; Background and aim: Heterozygous familial hypercholesterolemia (HeFH) is a genetic disease characterized by a heterogeneous phenotype. The assessment of cardiovascular (CV) risk is challenging for HeFH. Cholesterol burden (CB) allows to estimate the lifelong exposure to high levels of cholesterol. The aim of this study was to analyze the distribution of subclinical athero-sclerosis and the relationship between atherosclerosis and the CB in a sample of HeFH patients, focusing on sex-related differences. Methods and Results: 154 asymptomatic HeFH subjects underwent coronary-artery-calcium score (CACs) and Doppler ultrasound of carotid and femoral arteries. Yearly lipid…

Peripheral arterial atherosclerosismedicine.medical_specialtyEndocrinology Diabetes and Metabolism[SDV]Life Sciences [q-bio]Medicine (miscellaneous)030209 endocrinology & metabolismFamilial hypercholesterolemia030204 cardiovascular system & hematologyCoronary artery calcium03 medical and health scienceschemistry.chemical_compound0302 clinical medicineInternal medicineMedicineNutrition and Dieteticsbusiness.industryCholesterolmedicine.diseaseAtherosclerosisCardiovascular diseaseCardiovascular riskCalcium score3. Good healthFamilial hyper cholesterolemiaCholesterol burdenchemistrySubclinical atherosclerosisCardiologyCardiology and Cardiovascular Medicinebusiness[SDV.AEN]Life Sciences [q-bio]/Food and Nutrition
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<p>Endothelial Function in Obese Patients Treated with Bariatric Surgery</p>

2020

Purpose Bariatric surgery (BS) is becoming an increasingly frequent treatment option especially in people with morbid obesity, demonstrating that it is able to reduce total mortality and cardiovascular (CV) risk. Despite endothelial dysfunction is an essential requisite contributing to atherosclerosis and predicting CV events, only some studies have investigated the effects of BS on endothelial function with controversial results. In this study, the effects of weight loss on endothelial function were investigated in obese patients after BS and compared with patients after medical nutrition treatment (MNT). Patients and Methods Seventeen obese patients who underwent BS procedures (9 adjustab…

Pharmacologymedicine.medical_specialtybusiness.industry030209 endocrinology & metabolism030204 cardiovascular system & hematologymedicine.diseaseObesitySurgeryTotal mortality03 medical and health sciences0302 clinical medicineWeight lossSubclinical atherosclerosismedicine.arteryInternal MedicinemedicineMedical nutrition therapyEndothelial dysfunctionmedicine.symptomBrachial arterybusinessAfter treatmentDiabetes, Metabolic Syndrome and Obesity: Targets and Therapy
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